Hydrocodone and acetaminophen combination is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. Hydrocodone and acetaminophen combine to treat moderate pain. It works by blocking pain signals to your brain. Learn about Norco (hydrocodone / acetaminophen) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Hydrocodone Acetaminophen 5-325 is a widely prescribed painkiller, combining an opioid and a non-opioid analgesic. While effective for managing moderate to severe pain, its potential for misuse, dependence, and addiction raises significant concerns. Find patient medical information for Hydrocodone/Acetaminophen (Norco, Vicodin, others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Type: opioid (hydrocodone) + acetaminophen Dosage Forms: PO Common Trade Names: Norco Adult Dosing General Pain: 2.5-10mg hydrocodone/325mg Acetaminophen PO q4-6h Pediatric Dosing Not Currently recommended Special Populations Pregnancy Rating: C Lactation Risk Categories: possibly unsafe Renal Dosing Adult: none Pediatric: none Hepatic Dosing. Hydrocodone/acetaminophen is a narcotic drug used as a pain reliever to treat moderate to moderately severe pain and cough suppressant. Side effects include lightheadedness, dizziness, sedation, nausea, and vomiting. Hydrocodone/Acetaminophen is a prescription medication used to treat Moderate to Severe Pain. Learn about side effects, dosages, drug interactions, and more. Hydrocodone and acetaminophen is a Schedule II controlled substance. All branded hydrocodone and acetaminophen (Norco, Vicodin, Lortab, Hycet, Lorcet, Verdrocet, Xodol, Zamicet) have been discontinued, but generic hydrocodone and acetaminophen tablets and oral solution is still available. Detailed Acetaminophen / Hydrocodone dosage information for adults and children. Includes dosages for Pain; plus renal, liver and dialysis adjustments.