This guide compares prescription opioids (oxycodone and hydrocodone) against over-the-counter analgesics (acetaminophen, ibuprofen, and naproxen) across various pain conditions. Hydrocodone/Acetaminophen is a prescription medication used to treat Moderate to Severe Pain. Learn about side effects, dosages, drug interactions, and more. Learn about Norco (hydrocodone / acetaminophen) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Find patient medical information for Hydrocodone/Acetaminophen (Norco, Vicodin, others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Hydrocodone and acetaminophen combination is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated. Hydrocodone and acetaminophen is a Schedule II controlled substance. All branded hydrocodone and acetaminophen (Norco, Vicodin, Lortab, Hycet, Lorcet, Verdrocet, Xodol, Zamicet) have been discontinued, but generic hydrocodone and acetaminophen tablets and oral solution is still available. Hydrocodone/acetaminophen is a narcotic drug used as a pain reliever to treat moderate to moderately severe pain and cough suppressant. Side effects include lightheadedness, dizziness, sedation, nausea, and vomiting.